The act of administering medicine rectally is a selected technique of drug supply. This system includes inserting a drug, typically in suppository kind, into the rectum. The rectal mucosa, wealthy in blood vessels, facilitates absorption of the medicine into the bloodstream. This route will be notably advantageous when oral administration shouldn’t be possible as a consequence of elements comparable to nausea, vomiting, or unconsciousness.
This technique presents a number of advantages in sure medical eventualities. It could possibly bypass the first-pass metabolism within the liver, doubtlessly resulting in larger bioavailability of the drug. Moreover, rectal administration will be helpful in pediatric sufferers or people who’ve issue swallowing capsules. Traditionally, it has served as a significant different route for delivering medicines when different choices are restricted or contraindicated.
